New Study Links Long-Term Melatonin Use to Increased Heart Failure Risk
A recent study warns that adults with insomnia who use melatonin for an extended period face significantly higher risks concerning heart health. Melatonin, a popular over-the-counter sleep aid in the United States, is relied upon by nearly six million people to improve sleep quality.
Key Findings from the Research
- Long-term melatonin use is associated with a 90% greater risk of developing heart failure in adults with insomnia.
- These individuals are also more likely to be hospitalized or die from any cause within five years compared to those who do not use melatonin.
- Researchers analyzed health data from over 130,000 adults with insomnia who had no previous heart failure history.
- The study compared long-term melatonin users (one year or more) to non-users, revealing a marked increase in adverse outcomes.
- In the United Kingdom, where melatonin requires a prescription, individuals with at least two prescriptions 90 days apart exhibited an 82% higher risk of heart failure.
- Melatonin users showed nearly 3.5 times the likelihood of hospitalization for heart failure compared to non-users.
Context and Implications
Melatonin is widely regarded as a safe sleep supplement; however, this study highlights potential cardiovascular risks for long-term users, especially adults suffering from insomnia.
"Adults with insomnia who took melatonin for at least a year had a much higher chance of developing heart failure," said researchers at the American Heart Association Scientific Sessions 2025.
The findings stress the importance of consulting healthcare providers before prolonged melatonin use, especially for those with underlying health concerns.
Author's Summary
This study reveals a significant association between prolonged melatonin use in insomniacs and elevated heart failure risk, urging caution and medical guidance for sleep supplement users.