Tranexamic acid (TXA) has been widely used in total hip and total knee arthroplasty (THA and TKA) to reduce blood loss.
The commonly investigated routes of TXA administration include oral, intravenous, intra-articular, and topical methods.
A study by Feng et al aimed to evaluate and compare the efficacy and safety of oral versus intravenous tranexamic acid in primary total knee and hip arthroplasty.
The study systematically searched the PubMed, Web of Science, Cochrane Library, and Embase databases for relevant randomized controlled trials (RCTs).
Oral TXA is as effective and safe as IV TXA in patients undergoing hip and knee arthroplasty.
Author's summary: Oral TXA is effective in arthroplasty.