Long-Term Melatonin Use May Increase Heart Failure Risk
New research suggests that extended use of melatonin for sleep issues could pose unexpected cardiovascular dangers. Chronic melatonin users were found to have nearly double the risk of death and 3.5 times the chance of hospitalization due to heart failure.
Study Findings Presented at AHA 2025
A preliminary study shared at the American Heart Association's Scientific Sessions 2025 reported that adults suffering from chronic insomnia who took melatonin for a year or longer faced higher risks of developing heart failure, hospitalization for heart failure, and all-cause mortality compared to non-users.
The findings will be discussed at the AHA's annual meeting, held from November 7 to 10 in New Orleans, a major event for cardiovascular research and clinical updates.
Understanding Melatonin and Its Use
Melatonin is a hormone produced by the pineal gland that regulates the sleep-wake cycle, with levels rising at night and falling during the day. Synthetic melatonin, chemically identical to the natural hormone, is commonly used to manage insomnia and jet lag.
In the United States and many other countries, melatonin supplements are available over the counter. However, because they are not federally regulated in the U.S., the purity and dosage of these products can vary significantly.
Expert Advice
Though melatonin is widely considered safe, experts now recommend caution, especially with long-term use, due to the emerging evidence linking it to serious heart-related risks.
Author’s summary: Long-term melatonin use might carry serious heart failure risks, urging caution despite its reputation as a harmless sleep aid.